msi motherboard 8 ram slots - ASUS H110M-CS | 1 RAM SLOT NOT WORKING SOLUTION | FULL ... slot jago 888

If your motherboard has, for example, 4 or 8 open RAM slots, and you only have two sticks, there is only one specific combination you are supposed to use to plug your RAM sticks into the slots.

RAM slot: 4 slots (Up to 64GB) ... MSI Z390-A PRO Computer Motherboard.

So even if the RAM slots on your DDR5 RAM were to be physically backward compatible with DDR4 RAM slots, your motherboard wouldn’t know how to control the newer-gen RAM.